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Search Results for " bbb penetrant "

8

Compounds

Cat No. Product Name Synonyms Targets
T9146 Ms48107 Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Others
MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...
T7476 AS057278 3-Methylpyrazole-5-carboxylic acid Others
AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.
T32191 Irdabisant CEP-26401,CEP 26401,CEP26401 Histamine Receptor
Irdabisant (CEP-26401) (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant antagonist/inverse agonist of histamine H3 receptor (H3R) (rat H3R Ki= 7.2 nM, human H3R Ki= 2.0 nM). Irdabisant ex...
T60650 MAO-B-IN-13
MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant MAO-B inhibitor (IC50 = 10 nM). MAO-B-IN-13 shows neuroprotective and antioxidant activity which can be used in Parkinson’...
T36968 ARN-21934 Topoisomerase
ARN-21934 is a potent, highly selective, blood-brain barrier (BBB) penetrant inhibitor for human topoisomerase II α over β. ARN-21934 inhibits DNA relaxation with an IC50 of 2 μM as compared to the anticancer agent Etopo...
T73508 FLDP-5
FLDP-5, a blood-brain barrier (BBB) penetrant curcuminoid analogue, induces the production of Reactive Oxygen Species (ROS), DNA damage, and cell cycle S phase arrest. It demonstrates significant tumor-suppressive effect...
T9669 EST73502 hydrochloride
EST73502 hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with K i s of 64 nM and 118 nM for MOR and σ1R, respecti...
T61197 Irdabisant hydrochloride
Irdabisant hydrochloride (CEP-26401) is a selective, orally active, and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist, demonstrating high affinity with K*i values of 7.2 ...
TargetMol